Jeanette Henderson was born in Madison County, Florida. She is the twelfth of fifteen siblings. She attended public school until her senior year, obtained a GED from Lake County Area Vocational Tech in Leesburg, Florida, and pursued her dream of attending college. She earned an ASW from North Florida Junior College in Madison, Florida, in 1976, transferred to Valdosta State College (now Valdosta State University) and obtained a B.S. degree in Criminal Justice. She then earned a BSN from the Valdosta State College Nursing School. Jeannette Henderson is married to Thomas Henderson III, is a mother of five, and is presently employed as a Psychiatric Nurse.